RECOMBINANT INTRACELLULAR PATHOGEN IMMUNOGENIC COMPOSITIONS AND METHODS FOR USE

摘要

A prime-boost vaccine formulation for use in inducing a protective immune response in a prime-boost vaccine strategy, comprising a first priming immunogenic composition which is a Bacille-Calmette-Guerin (BCG) and a second boosting immunogenic composition which is a purified Mycobacteria major extracelluar protein. An immunogenic composition comprising a live intracellular pathogen wherein the pathogen is a growth regulatable recombinant Bacille-Calmette-Guérin (rBCG)