发明名称 |
PROCESS FOR PREPARATION OF CHIRAL AMLODIPINE SALTS |
摘要 |
<p>A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(-) Amlodipine and R(+) Amlodipine without isolation of the chiral free base wherein the product has optical purity ranging between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using L(+) or D(-) tartaric acid followed by reaction of the separated tartrate salt with an organic acid to obtain the salt corresponding to the acid used in ee ranging from 96- 99%.</p> |
申请公布号 |
KR20060086432(A) |
申请公布日期 |
2006.07.31 |
申请号 |
KR20067009616 |
申请日期 |
2006.05.17 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH |
发明人 |
JOSHI ROHINI RAMESH;JOSHI RAMESH ANNA;KARADE NILESH BAPURAO;GURJAR MUKUND KESHAV |
分类号 |
C07D211/90;C07B57/00 |
主分类号 |
C07D211/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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