摘要 |
Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject. |
申请人 |
VAXINNATE CORPORATION;POWELL, THOMAS, J.;NAKAAR, VALERIAN;SONG, LANGZHOU;HULEATT, JAMES, W.;MCDONALD, WILLIAM, F.;HEWITT, DUANE, D. |
发明人 |
POWELL, THOMAS, J.;NAKAAR, VALERIAN;SONG, LANGZHOU;HULEATT, JAMES, W.;MCDONALD, WILLIAM, F.;HEWITT, DUANE, D. |