TOPICAL TREATMENT OF SOLID TUMORS AND OCULAR NEOVASCULARIZATION

摘要

A topical method for treating various cancers, including cervical cancer, macular degeneration, melanoma and other skin cancers, by topical administration of a pharmaceutical composition comprising: formula (I) wherein X = O or S, Y is -OR<SUB>4</SUB>, -NHR<SUB>4</SUB>, -NHAc, -NHAIa, -NHSer, -NHGIu, -NHLys, -NHSuc, -NH(nitro)Arg, -NH(O)COR<SUB>4</SUB>, -NH(O)NHR<SUB>4</SUB>, -COOR<SUB>4</SUB>, where R<SUB>4</SUB> is H, C<SUB>1-6 </SUB>alkyl, phenyl, benzyl or phosphate; R<SUB>1</SUB> is selected from -OR, -NRR, and -SR where R is independently H, C<SUB>1-6</SUB> alkyl, phenyl, or benzyl; R<SUB>2</SUB> is selected from H or C<SUB>1-6 </SUB>alkyl; and R<SUB>3</SUB> is H, -OH, or -OR<SUB>5</SUB> where R<SUB>5</SUB> is C<SUB>1-6 </SUB>alkyl, phenyl or benzyl or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.