发明名称 |
SYNTHESIS OF SODIUM NARCISTATIN AND RELATED COMPOUNDS |
摘要 |
<p>The present invention involves use of the compounds narciclasine (2a) and 7-deoxy-narciclasine (2c), which are obtained via isolation from the medicinal plant species Narcissus (Amaryllidaceae), as precursors in a novel synthesis method in which each of these compounds are selectively hydrogenated to produce trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c). Also described herein is a novel synthesis method for producing sodium narcistatin (11) from narciclasine (2a). Further described herein are certain novel 3,4-cyclic phosphate prodrugs, including sodium-7-deoxynarcistatin (8), sodium-7-deoxy-transdihydronarcistatin (9), and sodium transdihydronarcistatin (10).</p> |
申请公布号 |
WO2006076726(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
WO2006US01658 |
申请日期 |
2006.01.17 |
申请人 |
STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE;PETTIT, GEORGE, R.;MELODY, NOELEEN |
发明人 |
PETTIT, GEORGE, R.;MELODY, NOELEEN |
分类号 |
A61K31/443;C07D413/08;C07D471/04;C07F9/28 |
主分类号 |
A61K31/443 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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