发明名称 Ribozymes to growth factor originating in human platelet
摘要 A ribozyme comprising the following nucleotide sequence (SEQ ID NO:14) (I): <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="offset" colwidth="56pt" align="left"/> <colspec colname="1" colwidth="161pt" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> <ENTRY>3'-GUGCCCCA GUACGGUG-5'</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY> A C</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY> A UGA</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY> G AGU</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY> N<SUP>3 </SUP>N<SUP>1</SUP></ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY> N<SUP>2</SUP></ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES> wherein A, C, G and U represent a ribonucleotide whose base component is adenine, cytosine, guanine and uracil, respectively, N<SUP>1 </SUP>and N<SUP>3 </SUP>are at least one pair of nucleotides capable of forming a complementary base pair with each other, and N<SUP>2 </SUP>is at least three nucleotides capable of forming a loop.
申请公布号 US7078390(B1) 申请公布日期 2006.07.18
申请号 US20020110274 申请日期 2002.04.10
申请人 GENTIER BIOSYSTEMS INCORPORATION 发明人 FUKUDA NOBORU
分类号 C07H21/04;A61K31/70;A61P9/00;A61P9/10;A61P9/12;C12N5/00;C12N15/113 主分类号 C07H21/04
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