| 发明名称 | 制备四取代咪唑衍生物及其新型晶体结构的方法 | ||
| 摘要 | 本发明涉及一种制备式(I)的四取代咪唑衍生物的方法，式中R<SUP>1</SUP>、R<SUP>2</SUP>、R<SUP>3</SUP>和R<SUP>4</SUP>在以下说明书中定义。本发明还涉及一种制备式(II)的化合物和式(II)的化合物的新型晶体结构的方法。 | ||
| 申请公布号 | CN1800178A | 申请公布日期 | 2006.07.12 |
| 申请号 | CN200510131799.9 | 申请日期 | 2002.02.22 |
| 申请人 | 奥索－麦克尼尔药品公司 | 发明人 | H·钟;S·杜伯克;S·米勒;A·罗斯勒;T·W·舒尔茨;D·J·科里;T·奥藤;D·G·瓦尔克;A·阿布德尔－梅吉 |
| 分类号 | C07D401/04(2006.01) | 主分类号 | C07D401/04(2006.01) |
| 代理机构 | 中国专利代理(香港)有限公司 | 代理人 | 李连涛 |
| 主权项 | 1.一种式(II)化合物的晶型：<img file="A2005101317990002C1.GIF" wi="852" he="658" />所述晶型具有下述X-射线粉末衍射峰：<tables id="table1" num="001"><table width="655"><tgroup cols="3"><colspec colname="c001" colwidth="24%" /><colspec colname="c002" colwidth="29%" /><colspec colname="c003" colwidth="47%" /><thead><row><entry morerows="1"> 角度°2θ</entry><entry morerows="1"> d-间距(_)</entry><entry morerows="1"> 相对强度(％)</entry></row></thead><tbody><row><entry morerows="1"> 7.206</entry><entry morerows="1"> 12.257</entry><entry morerows="1"> 100.0</entry></row><row><entry morerows="1"> 8.961</entry><entry morerows="1"> 9.861</entry><entry morerows="1"> 14.2</entry></row><row><entry morerows="1"> 10.617</entry><entry morerows="1"> 8.326</entry><entry morerows="1"> 24.8</entry></row><row><entry morerows="1"> 12.438</entry><entry morerows="1"> 7.110</entry><entry morerows="1"> 14.0</entry></row><row><entry morerows="1"> 15.500</entry><entry morerows="1"> 5.712</entry><entry morerows="1"> 33.7</entry></row><row><entry morerows="1"> 16.458</entry><entry morerows="1"> 5.382</entry><entry morerows="1"> 13.3</entry></row><row><entry morerows="1"> 17.360</entry><entry morerows="1"> 5.104</entry><entry morerows="1"> 17.2</entry></row><row><entry morerows="1"> 17.879</entry><entry morerows="1"> 4.957</entry><entry morerows="1"> 37.6</entry></row><row><entry morerows="1"> 18.343</entry><entry morerows="1"> 4.833</entry><entry morerows="1"> 19.2</entry></row><row><entry morerows="1"> 18.665</entry><entry morerows="1"> 4.750</entry><entry morerows="1"> 31.8</entry></row></tbody></tgroup></table></tables><tables id="table2" num="002"><table width="660"><tgroup cols="3"><colspec colname="c001" colwidth="23%" /><colspec colname="c002" colwidth="29%" /><colspec colname="c003" colwidth="46%" /><thead><row><entry morerows="1"> 19.126</entry><entry morerows="1"> 4.637</entry><entry morerows="1"> 16.1</entry></row></thead><tbody><row><entry morerows="1"> 19.943</entry><entry morerows="1"> 4.448</entry><entry morerows="1"> 21.9</entry></row><row><entry morerows="1"> 20.491</entry><entry morerows="1"> 4.331</entry><entry morerows="1"> 30.8</entry></row><row><entry morerows="1"> 21.469</entry><entry morerows="1"> 4.135</entry><entry morerows="1"> 52.9</entry></row><row><entry morerows="1"> 21.891</entry><entry morerows="1"> 4.057</entry><entry morerows="1"> 59.8</entry></row><row><entry morerows="1"> 22.371</entry><entry morerows="1"> 3.971</entry><entry morerows="1"> 58.7</entry></row><row><entry morerows="1"> 22.778</entry><entry morerows="1"> 3.901</entry><entry morerows="1"> 12.0</entry></row><row><entry morerows="1"> 23.159</entry><entry morerows="1"> 3.837</entry><entry morerows="1"> 51.0</entry></row><row><entry morerows="1"> 23.870</entry><entry morerows="1"> 3.725</entry><entry morerows="1"> 20.8</entry></row><row><entry morerows="1"> 24.526</entry><entry morerows="1"> 3.627</entry><entry morerows="1"> 15.5</entry></row><row><entry morerows="1"> 24.704</entry><entry morerows="1"> 3.601</entry><entry morerows="1"> 25.9</entry></row><row><entry morerows="1"> 25.113</entry><entry morerows="1"> 3.543</entry><entry morerows="1"> 14.7</entry></row><row><entry morerows="1"> 26.368</entry><entry morerows="1"> 3.377</entry><entry morerows="1"> 11.0</entry></row><row><entry morerows="1"> 27.674</entry><entry morerows="1"> 3.221</entry><entry morerows="1"> 10.5</entry></row><row><entry morerows="1"> 28.088</entry><entry morerows="1"> 3.174</entry><entry morerows="1"> 18.3</entry></row><row><entry morerows="1"> 28.896</entry><entry morerows="1"> 3.087</entry><entry morerows="1"> 21.3</entry></row><row><entry morerows="1"> 29.291</entry><entry morerows="1"> 3.047</entry><entry morerows="1"> 19.4</entry></row><row><entry morerows="1"> 30.201</entry><entry morerows="1"> 2.9568</entry><entry morerows="1"> 10.6</entry></row><row><entry morerows="1"> 30.501</entry><entry morerows="1"> 2.9284</entry><entry morerows="1"> 13.3</entry></row></tbody></tgroup></table></tables> | ||
| 地址 | 美国新泽西州 | ||