COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE FORMATION OF AMYLOID FIBRILS

摘要

SUMMARY The present invention provides new amyloidogenesis inhibiting compounds of formula (I):
in which R 1 is a -NR a R b group, where R a and R b , independently, are a hydrogen atom or a C 1 -C 6 alkyl group; -OR c group, where R c is a hydrogen atom or a C 1 -C 6 alkyl group; a glycosyl; a C 1 -C 6 polyhydroxyalkyl; or a -NH-CH(R d )-COOR e group, where R d is a side chain of one of the 20 natural alpha-amino acids in either of their two enantiomerically pure forms L or D, and R e is a hydrogen atom or a C 1 -C 6 alkyl group; and R 2 is a hydrogen atom, a C 1 -C 6 alkyl group, a glycosyl; a C 1 -C 6 polyhydroxyalkyl; -C(=O)-R f group, where R f is a C 1 -C 6 alkyl group; or a -CH 2 -COO-R g group, where R g is a hydrogen atom or a C 1 -C 6 alkyl group;
and pharmaceutically acceptable salts thereof, which are useful in the treatment of neurodegenerative diseases, among others.