发明名称 Cinacalcet
摘要 Inorganic ion receptor modulating cpds. of formulae (I), (II) and (III) and their salts and complexes in the case of (I) and (II) are new, in which Ar2 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X1 ; X1 = lower alkyl, halo, lower alkoxy, lower thioalkyl, methylenedioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN or acetoxy; Ar1 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X2 ; X2 = as for X1 or N(CH3)2, phenyl, phenoxy, benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl or ethylenedioxy; Ar3 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X3 ; X3 = as for X1 or benzyl, benzyloxy, dimethylbenzyl, NO2, CHO, CH3CH(OH), N(CH3)2, acetyl or ethylenedioxy; Ar4 = as for Ar2; Ar5 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X4 ; X4 = as for X1 or benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl, ethylenedioxy or -CH=CH-phenyl; Ar6= naphthyl or phenyl which are opt. substd. with 0-5 substits. X5 ; X5 = as for X1 or acetyl, carbomethoxy or OCH2C(O)C2H5; q = 0-3; R = H or lower alkyl; R9, R11, R12 = H or CH3; R8 = H or phenyl; R10 = H, CH3 or phenyl.
申请公布号 LU91182(I2) 申请公布日期 2006.07.11
申请号 LU20050091182C 申请日期 2005.07.18
申请人 NPS PHARMACEUTICALS INC. 发明人
分类号 C07C211/27;A61K31/135;A61K31/137;A61K31/165;A61K31/215;A61K31/34;A61K31/343;A61K31/357;A61K31/36;A61K31/38;A61K31/381;A61K31/40;A61K31/445;A61K31/4468;A61P3/00;A61P3/14;A61P9/08;A61P9/12;A61P13/12;A61P19/00;A61P19/08;A61P19/10;A61P35/00;A61P43/00;C07C211/28;C07C211/29;C07C211/30;C07C211/31;C07C211/35;C07C211/38;C07C211/42;C07C215/08;C07C215/48;C07C217/16;C07C217/54;C07C217/56;C07C217/58;C07C217/60;C07C217/62;C07C219/28;C07C223/02;C07C225/16;C07C229/38;C07C255/58;C07C317/32;C07C323/32;C07D207/08;C07D207/323;C07D211/58;C07D215/14;C07D307/79;C07D317/58;C07D317/64;C07D319/18;C07D333/54;G01N33/566;G01N33/68 主分类号 C07C211/27
代理机构 代理人
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