| 发明名称 |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| 摘要 |
The isoquinoline compounds of formula (I) are VR1 antagonists that are useful in treating pain, inflammation, thermal hyperalgesia, urinary incontinence and bladder over activity. The "R", "Z" and "L" variables are defined in the disclosure and the "X" variables are defined as follows: X<SUB>1 </SUB>is CR<SUB>1</SUB>; X<SUB>2 </SUB>is selected from the group consisting of N and CR<SUB>2</SUB>; X<SUB>3 </SUB>is selected from the group consisting of N and CR<SUB>3</SUB>; X<SUB>4 </SUB>is CR<SUB>4</SUB>; and X<SUB>5 </SUB>is selected from the group consisting of N and C.
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| 申请公布号 |
US7074805(B2) |
申请公布日期 |
2006.07.11 |
| 申请号 |
US20030364210 |
申请日期 |
2003.02.11 |
| 申请人 |
ABBOTT LABORATORIES |
发明人 |
LEE CHIH-HUNG;BAYBURT EROL K.;DIDOMENICO, JR. STANLEY;DRIZIN IRENE;GOMTSYAN ARTHUR R.;KOENIG JOHN R.;PERNER RICHARD J.;SCHMIDT, JR. ROBERT G.;TURNER SEAN C.;WHITE TAMMIE K.;ZHENG GUO ZHU |
| 分类号 |
A61K31/47;C07D209/08;C07D217/00;C07D217/02;C07D217/22;C07D217/24;C07D217/26;C07D231/56;C07D237/28;C07D401/12;C07D405/12;C07D521/00 |
主分类号 |
A61K31/47 |
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