METHOD OF INHIBITING TELOMERASE ACTIVITY AND INHIBITOR

摘要

[PROBLEMS] To provide a method of inhibiting telomerase activity and a method of enabling the prevention and/or treatment of a disease caused by the enhancement of telomerase activity by finding a protein involved in regulation of telomerase activity. [MEANS FOR SOLVING PROBLEMS] A method of facilitating the degradation of telomerase characterized by inhibiting the binding of TERT (telomerase catalytic subunit) and USP21, the binding of NEDD8-modified TERT and USP21, or the removal of NEDD8 from NEDD8-modified TERT by USP21; a method of inhibiting telomerase activity using the method of facilitating the degradation; a method of identifying a compound that inhibits the binding or the removal of NEDD8, a telomerase activity inhibitor comprising the compound; a preventing and/or therapeutic agent for a disease caused by the enhancement of telomerase activity comprising the inhibitor, and a preventive and/or therapeutic method for the disease and a reagent kit using the inhibition method or the inhibitor.