Urea substituted imidazopyridines and pharmaceutical compositions for inducing cytokine biosynthesis and treating viral and neoplastic diseases

摘要

A compound of formula (I) is described wherein: X is alkylene or alkenylene; Y is -CO- or -CS-; Z is -NR6-, -NR6-CO-, -NR6-SO2- or -NR7-; R1 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl each which may be unsubstituted or substituted; R2 is selected from H, alkyl, alkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl-O-alkyl, alkyl-S-alkyl, alkyl-O-aryl, alkyl-S-aryl, alkyl-O-alkenyl, alkyl-S-alkenyl and alkyl or alkenyl substituted; R3 and R4 are selected from hydrogen, alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialkylamino and alkylthio; R5 is H or C1-10 alkyl, or R5 can join with X to form a ring that contains one or two hetero atoms; R6 is H or C1-10alkyl; R7 is H or C1-10alkyl which may be interrupted by a heteroatom or when R1 is alkyl, R7 and R1 can join to form a ring. A pharmaceutical composition comprising the compound is useful for inducing cytokine biosynthesis, in treating viral disease and for treating a neoplastic disease.