Novel 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for making same and pharmaceutical compositions containing same

摘要

1,2,3-substituted indolizine derivatives of formula (I) are disclosed, wherein the variables are as defined in the specification. These compounds of formula (I) are inhibitors of basic fibroblast growth factors (FGFs) and are suitable for the treatment of carcinomas of the lung, breast, prostate, esophagus, colon and stomach, melanomas, gliomas, lymphomas, and leukemias; and they are also suitable for the treatment of atherosclerosis, post-angioplasty restinosis, diseases linked to complications which appear following the fitting of endovascular prostheses and/or aorto-coronary artery by-pass surgery or other vascular transplants, cardiac hypertrophy or diabetic retinopathies.