METHOD FOR BIOTRANSFORMATION OF THE CLYCLOSPORIN COMPOUND ISA247

摘要

A method of producing metabolites of a xenobiotic compound by biotransformation using a microorganism, wherein the xenobiotic compound is cyclosprorm ISA247, which is delivered to the microorganism in a mixture with a surfactant The method can be scaled up to produce large quantities of metabolites by, for example, biotransformation in a reactor The metabolites produced by the present method can be used for antibody production, as standards in therapeutic dose monitoring, or in pharmaceutical applications