发明名称 |
TARGET PHYSIOLOGICAL FUNCTION INACTIVATOR USING PHOTOSENSITIZER-LABELED FLUORESCENT PROTEIN |
摘要 |
An object of the present invention is to provide a method of generating reactive oxygen species in a light irradiation-dependent manner, so as to inactivate any target physiological function. The present invention provides a target physiological function inactivator which consists of a photosensitizer-labeled fluorescent protein, wherein fluorescence resonance energy transfer (FRET) from the fluorescent protein to the photosensitizer occurs as a result of light irradiation, so that the photosensitizer can be excited to generate reactive oxygen species. |
申请公布号 |
CA2591871(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
CA20052591871 |
申请日期 |
2005.12.21 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY;RIKEN |
发明人 |
NAGAI, TAKEHARU;MIYAWAKI, ATSUSHI |
分类号 |
A61K41/00;A61K38/16;C07D311/82;C07K14/435;C07K19/00 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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