发明名称 |
Synthetic receptors, libraries and uses thereof |
摘要 |
Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or different and may be straight chain, cyclic or branched. The template may be linked to an identifier which is unique to each synthetic receptor. Although the identifier may be directly attached to the template, it is more common and preferable that the template be covalently linked to a solid support which is itself linked to the identifier. Methods of preparing synthetic receptors and libraries of synthetic receptors are also disclosed as are methods for assaying the libraries to determine which receptors have various desirable characteristics. Among the desirable characteristics are (a) the ability to bind an acceptor molecule; (b) biological activity; (c) the ability to catalyze or inhibit a reaction and (d) potential utility for separating compounds in chromatography.
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申请公布号 |
US7067326(B2) |
申请公布日期 |
2006.06.27 |
申请号 |
US19960676143 |
申请日期 |
1996.10.24 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
STILL W. CLARK;LI GE;WENNEMERS HELMA |
分类号 |
G01N33/543;G01N33/566;C07C237/10;C07C271/22;C07H21/04;C07J9/00;C07J41/00;C07J51/00;C07K1/04;C07K5/00;C07K5/12;C07K7/06;C07K7/23;C07K17/04;C12Q1/25;C12Q1/68;C40B70/00 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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