发明名称 |
Method to provide bacterial ghosts provided with antigens |
摘要 |
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
|
申请公布号 |
US7067639(B2) |
申请公布日期 |
2006.06.27 |
申请号 |
US20020321857 |
申请日期 |
2002.12.16 |
申请人 |
APPLIED NANOSYSTEMS B.V. |
发明人 |
LEENHOUTS CORNELIS J.;RAMASAMY RANJAN;STEEN ANTON;KOK JAN;BUIST GIRBE;KUIPERS OSCAR P. |
分类号 |
A61K39/00;A61K38/00;A61K39/02;A61K39/38;A61K45/00;A61K47/00;C07K1/00;C07K14/00;C07K14/335;C07K16/00;C07K17/00;C07K19/00;C12N1/00;C12N15/31;C12N15/63 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|