СПОСОБ ПОЛУЧЕНИЯ ГЕПТАПЕПТИДА, ОБЛАДАЮЩЕГО ПСИХОСТИМУЛИРУЮЩЕЙ АКТИВНОСТЬЮ, ТРИПЕПТИД ДЛЯ ЕГО ПОЛУЧЕНИЯ И ТЕТРАПЕПТИД ДЛЯ ЕГО ПОЛУЧЕНИЯ

摘要

FIELD: pharmaceutical chemistry. ^ SUBSTANCE: invention relates to method for production of heptapeptide of general formula: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH having psychostimulating activity. Synthesis is carried out by condensation of C-terminal protected tripeptide of formula HCl.H-Pro-GlY-Pro-OX, wherein X is protective group, with protected N-terminal tetrapeptide of formula Y-Thr-Lys(Y1)-Pro-Arg-OH, wherein Y and Y1 are protective groups, and obtained protected heptapeptide of formula Y-Thr-Lys(Y1)-Pro-Arg-Pro-Gly-Pro-OX is treated with deprotecting reagents to remove protective groups and target product is isolated by chromatography method. Also described are tripeptide of formula HCl.H-Pro-GlY-Pro-OBzl and tetrapeptide of formula Boc-Thr-Lys-(Boc)-Pro-Arg-OH as intermediates for synthesis of heptapeptide of general formula: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH. ^ EFFECT: simplified process; increased yield of target product. ^ 4 cl, 7 ex