CHELERYTHRINE, ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BIPOLAR DISORDER AND OTHER COGNITIVE DISORDERS.

摘要

The present invention relates to the use of chelerythrine and chelerythrine analogs in pharmaceutical compositions for the treatment of prefrontal cortical cognitive disorders, including bipolar disorder, among others. Pharmaceutical compositions according to the present invention comprise an effective amount of a compound or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof according to the structure: formula (I) or formula (II) wherein: R1 and R2 are independently selected from H, C1-C3alkyl, F, Cl, Br, I, OH, O(C1-C6 alkyl), O-C(=O)-(C1-C6)alkyl or C(=O)-O-(C1-C6)alkyl; R3 is H or a C1-C6alkyl group; R4, R5, R6 , R7 and R8 are independently selected from H, C1-C6alkyl, F, Cl, Br, I, OH, -(CH2)nO(C1-C6alkyl), -(CH2)nO-C(=O)-(C1-C6)alkyl or -(CH2)n C(=O)-O-(C1-C6)alkyl; R9 and R10 are independently H, C1-C6alkyI or together form a -(CH2)m-group to produce a 5-7-membered ring; n is from 0 to 5; m is from 1 to 3; and A- is a pharmaceutically acceptable anion of a pharmaceutical salt, which forms a salt with the quaternized amine group, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient.