摘要 |
FIELD: organic chemistry, biochemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new derivatives of mycanolide of the formula (I): corresponding to the general subformulae (I)1 and (I)2 wherein L, R1 and R2 have values given in the invention description. Also, invention relates to a medicinal agent and pharmaceutical composition based on compounds of the formula (I), and to using compounds of the formula (I) for preparing a medicinal agent designated for inhibition of activity of DNA polymerases and treatment of diseases arising as result of anomalous cellular proliferation. Invention provides preparing new derivatives of mycanolide possessing the valuable pharmaceutical effect. ^ EFFECT: valuable medicinal and biochemical properties of derivatives. ^ 12 cl, 2 tbl, 52 ex |