| 摘要 |
The invention relates to derivatives corresponding to formula I: in which X is an alkyl-(CH<SUB>2</SUB>)<SUB>n</SUB>- chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from -OH, -OR, -COOH, -COOR, -COH, -COR, -NH<SUB>2</SUB>, -NH(R), -NH(R,R'), -SH, -SR and CN, Ra is H or -(CH<SUB>2</SUB>)<SUB>n'</SUB>-Y, with n'=0, 1, 2 or 3 and Y and -CH<SUB>3</SUB>, -COOH, -COOR, -CN, -OH, -OR, SR, or an aryl group optionally substituted with Rb, R and R' represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
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