| 摘要 |
FIELD: immunology, cell therapy. ^ SUBSTANCE: claimed composition contains heat shock protein of HSP family or fragment thereof and tumor-specific peptide selected from group containing MAGE-A1, -A2, -A3, gp100, HER2/NEU, EGFRvIII or fragment thereof non-covalently bound to said protein, wherein non-covalent bond is provided by preliminary incubation of components under physiological conditions with adenosine diphosphate. As heat shock protein composition contains protein selected from group containing DnaK from M. tuberculosis, M. bovis or E. coli or human HSP 70 protein. Tumor-specific peptide fragments are described in table represented in description. Additionally composition contains immunomodulator selected from group containing INFalpha, INFgamma, TNFalpha, IL-2, -4, -6 or combination thereof and pharmaceutical carrier. Also disclosed are cell preparation which represents isolated and washed dendrite leucocytes activated by incubation with new composition as well as method for tumor immunotherapy or immunoprophylaxis by parenteral administration of composition or cell preparation in effective dose. ^ EFFECT: new antitumor preparation of improved effectiveness. ^ 8 cl, 1 tbl, 8 ex, 3 dwg |
