USE OF ENDOSIALIN BINDING PROTEINS TO ISOLATE ENDOSIALIN POSITIVE CELLS

摘要

Monoclonal antibodies and other proteins that specifically bind to cells positive for endosialin are provided. The antibodies and proteins are useful in the isolation of endosialin-positive cells, particularly cells associated with neovascularization associated with cancer and neovascular disease. The invention is also related to cells that are isolated using monoclonal antibodies; antibody derivatives, such as chimeric and humanized monoclonal antibodies; antibody fragments; mammalian cells expressing the monoclonal antibodies, derivatives and fragment; and methods of detecting and isolation endosialin-positive cells using the antibodies, derivatives and fragments.