发明名称 |
Compounds resistant to metabolic deactivation and methods of use |
摘要 |
Therapeutic compounds having increased resistance to deamination and inactivation by metabolic enzymes are provided. The compounds include nucleotide analogs and nucleotide analogs, derivatized with aminal and/or thioaminal groups to prevent deamination of free amine. The compounds can be used in a variety of treatments, including treatment of neoplastic disorders, infections from fungal or fungal-like organisms, and infections from parasites.
|
申请公布号 |
US2006122144(A1) |
申请公布日期 |
2006.06.08 |
申请号 |
US20050145550 |
申请日期 |
2005.06.02 |
申请人 |
KANE ROBERT R;CHANG HUI-MIN |
发明人 |
KANE ROBERT R.;CHANG HUI-MIN |
分类号 |
A61K31/7076;A61K31/70;A61P35/02;C07H19/04;C07H19/16 |
主分类号 |
A61K31/7076 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|