TOXIN COMPOUNDS WITH ENHANCED MEMBRANE TRANSLOCATION CHARACTERISTICS

摘要

The present invention relates to a compound comprising a toxin linked to a translocator. Non-limiting examples of toxins of the present invention are botulimum toxin, butyricum toxin, tetani toxins and the light chains thereof. In some embodiments, the translocator of the present invention comprises a protein transduction domain. Preferred translocators are selected from ciliary neurotrophic factor, caveolin, interleukin 1 beta, thioredoxin, fibroblast growth factor-1, fibroblast growth factor-2, Human beta-3, integrin, lactoferrin, Engrailed, Hoxa-5, Hoxb-4 and Hoxc-8. Preferred protein transduction domains are penetrating peptide, Kaposi fibroblast growth factor membrane-translocating sequence, nuclear localization signal, transportan, herpes simplex virus type 1 protein 22, human immunodeficiency virus transactivator protein.