发明名称 |
NANOSPHERE/MICROSPHERE DELIVERY SYSTEM FOR THE TREATMENT OF SPINAL CORD INJURY |
摘要 |
A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal cord injury in a mammal having the same is provided. The biodegradable nanosphere/ microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided. |
申请公布号 |
WO2005122734(A3) |
申请公布日期 |
2006.06.08 |
申请号 |
WO2005US20730 |
申请日期 |
2005.06.14 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;OSTERHOUT, DONNA J.;HASENWINKEL, JULIE M.;STELZNER, DENNIS J. |
发明人 |
OSTERHOUT, DONNA J.;HASENWINKEL, JULIE M.;STELZNER, DENNIS J. |
分类号 |
A61F2/00;A61K9/00;A61K9/16;A61K9/50;A61K9/51;A61K9/58 |
主分类号 |
A61F2/00 |
代理机构 |
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地址 |
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