ISOXAZOLINE-INDOLE DERIVATIVES WITH AN IMPROVED ANTIPSYCHOTIC AND ANXIOLYTIC A IVITY

摘要

The present invention relates to novel isoxazoline-indole derivatives according to Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, w ith a binding affinity towards dopamine receptors, in particular towards dopamine D<SUB>2</SUB> and/or D<SUB>3</SUB> receptors, with selective serotonin reuptake inhibition (SSRI) properties and showing an affinity for the 5-HT<SUB>1A</SUB> receptor, pharmaceutical compositions comprising the compounds according to the invention, the use thereof for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic disorders, most in particular schizophrenia and processes for their production, wherein the variables are further defined in the application.