发明名称 |
2-Aminoaryloxazole compounds as tyrosine kinase inhibitors |
摘要 |
The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
|
申请公布号 |
WO2005040139(A8) |
申请公布日期 |
2006.06.01 |
申请号 |
WO2004IB03698 |
申请日期 |
2004.10.22 |
申请人 |
AB SCIENCE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT CURIE |
发明人 |
MOUSSY, ALAIN;WERMUTH, CAMILLE;GRIERSON, DAVID;BENJAHAD, ABDELLAH;CROISY, MARTINE;CIUFOLINI, MARCO;GIETHLEN, BRUNO |
分类号 |
C07D263/48;C07D413/04;C07D413/14 |
主分类号 |
C07D263/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|