发明名称 |
ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE |
摘要 |
A process for preparing 8-substituted oxy-5-((R)-2-halo-l-hydroxy-ethyl)-(1 H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(a-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-l-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula (I) or (II), wherein M, L, X, R<SUP>1</SUP>, R<SUP>2</SUP> and R<SUP>3</SUP> have the meanings as indicated in the specification. |
申请公布号 |
WO2005123684(A3) |
申请公布日期 |
2006.06.01 |
申请号 |
WO2005EP06686 |
申请日期 |
2005.06.21 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;LOHSE, OLIVIER;VOGEL, CASPAR;ABEL, STEPHAN |
发明人 |
LOHSE, OLIVIER;VOGEL, CASPAR;ABEL, STEPHAN |
分类号 |
C07D215/26;C07D215/00;C07D251/26 |
主分类号 |
C07D215/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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