发明名称 |
TRANSGENIC MICE HAVING A HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) PHENOTYPE, EXPERIMENTAL USES AND APPLICATIONS |
摘要 |
The present invention relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2+HLA-DR1+&bgr;2m°IA&bgr;°. The invention also relates to methods of using a transgenic mouse of the invention. |
申请公布号 |
EP1659858(A2) |
申请公布日期 |
2006.05.31 |
申请号 |
EP20040744033 |
申请日期 |
2004.07.05 |
申请人 |
INSTITUT PASTEUR |
发明人 |
AURIAULT, CLAUDE;PANCRE, VERONIQUE;LONE, YU-CHUN;PAJOT, ANTHONY;LEMONNIER, FRANCOIS |
分类号 |
A01K67/027;A61K49/00;C07K14/74;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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