发明名称 |
Injectable multimodel polymer depot compositions and uses thereof |
摘要 |
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt% at 25°C, in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implantable beneath a patient's body surface by injection. |
申请公布号 |
ZA200501645(B) |
申请公布日期 |
2006.05.31 |
申请号 |
ZA20050001645 |
申请日期 |
2005.02.24 |
申请人 |
ALZA CORPORATION |
发明人 |
GUOHUA CHEN;PAUL HOUSTON;LOTHAR KLEINER;JEREMY WRIGHT |
分类号 |
A61K47/38;A61K;A61K9/00;A61K9/06;A61K9/10;A61K9/14;A61K9/20;A61K47/08;A61K47/10;A61K47/12;A61K47/14;A61K47/22;A61K47/24;A61K47/32;A61K47/34;A61K47/36;A61L31/00 |
主分类号 |
A61K47/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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