| 摘要 |
Disclosed are compounds of formula (I), wherein: X is alkylene or alkenylene, R1 is optionally substituted alkyl or cycloalkyl, R2 is H or lower alkyl, or R1 and R2 are taken together to form alkylene, n is 1 or 2, Y is OCONR7, CONR7, CSNR7, NR7CO or NR7CS, R7 is H or alkyl, and Z is optionally substituted alkyl, alkenyl, amino, alkoxy, carbocyclyl or heterocyclyl. The compounds are used for the manufacture of medicaments for use as NPY Y5 receptor antagonist, particularly as anti-obestic agents.
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| 分类号 |
A61K;A61K31/00;A61K31/18;A61K31/341;A61K31/351;A61K31/357;A61K31/37;A61K31/381;A61K31/4015;A61K31/402;A61K31/4035;A61K31/41;A61K31/415;A61K31/4196;A61K31/42;A61K31/421;A61K31/423;A61K31/425;A61K31/428;A61K31/433;A61K31/44;A61K31/4409;A61K31/4453;A61K31/451;A61K31/495;A61K31/4965;A61K31/505;A61K31/535;A61K31/5375;A61K31/63;A61K31/635;A61P;A61P3/04;A61P43/00;C07C;C07C311/06;C07C311/07;C07C311/08;C07C311/14;C07C311/20;C07C311/21;C07C311/46;C07C323/40;C07D;C07D207/09;C07D207/12;C07D207/16;C07D209/08;C07D209/48;C07D209/88;C07D211/08;C07D211/58;C07D211/62;C07D213/75;C07D213/82;C07D215/36;C07D215/38;C07D217/04;C07D219/10;C07D231/12;C07D231/16;C07D231/56;C07D233/68;C07D239/42;C07D241/02;C07D261/08;C07D265/30;C07D277/46;C07D277/56;C07D277/70;C07D285/06;C07D295/135;C07D307/02;C07D307/68;C07D307/91;C07D311/16;C07D317/66;C07D333/38;C07D333/72;C07D521/00;(IPC1-7):A61K31/18;C07D33/54;A61K31/537;A61K31/343;A61K31/445;4035,47;4035,47416;4035,4736;4035,47505;37,40,4;37,40,4433;37,40,4495;37,40,4426;4409,42;4409,4247;4409,42423;4409,42421;4409,4242;4409,42416;4409,42537;4409,42506;4409,42454;4525,45;4525,45453;4525,45357;4525,45353;4525,45351;4525,45216;C07D333/20;A61K31/27;A61K31/275;A61K31/196;C07D285/14;C07D309/06;C07D309/04;C07D309/10;C07D309/12;C07D311/58;C07D285/12;C07C311/42;C07C311/09;C07D319/18;C07D417/12;C07D405/12;C07D409/12;C07D401/12;C07D413/12;C07D413/04;C07D211/70;C07D207/335;C07D211/26;C07D311/18;C07D207/14;C07D257/04;C07D295/12;C07D213/40;C07D277/72;C07D263/56;C07D263/32 |
主分类号 |
A61K |
