| 摘要 |
The invention relates to a biomimetic process for coating a substrate, particularly a medical device, with a biomimetic composition, which comprises: a) producing batchwise in a closed system an acidified biomimetic composition comprising a saline aqueous mixture containing calcium-, magnesium-, phosphate-, bicarbonate ions and a bioactive substance, b) contacting the substrate with said biomimetic composition and c) storing the biomimetic composition in contact with the substrate and allowing a gradual increase of the pH to occur and to cause precipitation of salts and co-precipitation of the bioactive substance on said substrate and to obtain a coated substrate. |
