发明名称 |
Method, computing routine, device for predicting properties of mhc/peptide complexes, and data and peptides produced therefrom |
摘要 |
The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.
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申请公布号 |
US2006111554(A1) |
申请公布日期 |
2006.05.25 |
申请号 |
US20050516628 |
申请日期 |
2005.09.07 |
申请人 |
LASTERS IGNACE;DESMET JOHAN |
发明人 |
LASTERS IGNACE;DESMET JOHAN |
分类号 |
C07K14/74;G06F19/16;G06F19/18 |
主分类号 |
C07K14/74 |
代理机构 |
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主权项 |
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地址 |
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