发明名称 |
Antigene locks and therapeutic uses thereof |
摘要 |
An oligonucleotide based therapeutic strategy, called anti-gene locks, is described which specifically kills cells based on their genotype. The strategy employs oligonucleotides with arms and a backbone that are complementary to both strands of the gene target. Anti-gene locks bind in vitro in a sequence dependent fashion and inhibit DNA synthesis. In bacterial cells containing an episome target, they cause elimination of the extra-chromosomal DNA structure. When the target is present in the bacterial or human genome, they selectively kill the majority of these cells.
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申请公布号 |
US2006111312(A1) |
申请公布日期 |
2006.05.25 |
申请号 |
US20050505308 |
申请日期 |
2005.09.07 |
申请人 |
THE JOHN HOPKINS UNIVERSITY |
发明人 |
ESHLEMAN JAMES R.;PARKER ANTONY R. |
分类号 |
A61K48/00;A61K38/00;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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