INHIBITORS OF 11????-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1)

摘要

The invention relates to sulfonamide compounds of formula (I) wherein A, B, R<SUP>1</SUP>and X<SUP>1</SUP> to X<SUP>3</SUP> have the meaning as cited in the description and the claims. For example A is biphenyl, B is 2-morpholin-4-yl-2-oxo-ethyl, R<SUP>1</SUP> is H and X<SUP>1</SUP> to X<SUP>3</SUP> are CH. Said compounds are useful as 11ß-HSD1 inhibitors. The invention also relates to the preparation of such compounds as well as the production and use as medicament.