发明名称 |
Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy |
摘要 |
Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Also provided is a synthetic peptide-containing pharmaceutical composition as a unit dose comprising an aqueous formulation comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Further provided is a method of treating HIV infection by administering to an HIV-infected individual a pharmaceutical composition according to the present invention.
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申请公布号 |
US7045552(B2) |
申请公布日期 |
2006.05.16 |
申请号 |
US20030663589 |
申请日期 |
2003.09.16 |
申请人 |
TRIMERIS, INC. |
发明人 |
HEILMAN DAVID;DI JIE;BRAY BRIAN |
分类号 |
A61K38/00;A61K47/30;A61K9/00;A61K38/16;A61K47/10;A61K47/26 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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