发明名称 |
PROCESS FOR PRODUCING LOW-MELTING CRYSTAL OF FREE DISOPYRAMIDE BASE |
摘要 |
The present invention provides a production method of a low melting point type crystal of disopyramide free base, which comprises a step of dissolving disopyramide free base in a solvent, a step of crystallizing the disopyramide free base from the obtained solution and a step of aging the crystal of the disopyramide free base, wherein the solvent is a mixed solvent of toluene and one or two kinds of hydrocarbon solvents selected from heptane and hexane. According to the present invention, a method capable of stably producing a low melting point type crystal of disopyramide free base on an industrial scale in a high yield can be provided.
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申请公布号 |
EP1655286(A1) |
申请公布日期 |
2006.05.10 |
申请号 |
EP20040746514 |
申请日期 |
2004.06.21 |
申请人 |
SUMITOMO CHEMICAL COMPANY, LIMITED |
发明人 |
YAMAMOTO, TOMIAKI;INOUE, HARUYUKI, |
分类号 |
A61K31/4402;A61P9/06;C07D213/56;(IPC1-7):C07D213/56;B01D9/02;A61K31/440 |
主分类号 |
A61K31/4402 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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