发明名称 АРИЛЗАМЕЩЕННЫЕ ПИРАЗОЛАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ
摘要 The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R 2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl. The compounds are surprisingly advantageous in preparing medicaments for treating p38 kinase related conditions and/or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient.
申请公布号 RU2005135162(A) 申请公布日期 2006.05.10
申请号 RU20050135162 申请日期 2004.05.03
申请人 БРИСТОЛ-МАЕРС СКВИББ КОМПАНИ (US) 发明人 ДИКМАН Аларик (US);ДЭС Джагабандху (US);ЛЕФТЕРИС Катерина (US);ЛИУ Чанджиан (US);ЖАО Ралин (US);ЧЕН Бэнг-Чи (US);ВРОБЛЕСКИ Стивен Т. (US)
分类号 C07D231/18;A61K;A61K31/415;A61K31/4152;A61K31/4155;A61K31/416;A61K31/4439;A61K31/497;A61K31/501;A61K31/506;A61K31/535;A61K31/675;C07D;C07D231/04;C07D231/14;C07D401/04;C07D401/12;C07D403/04;C07D405/12;C07D413/12;C07D413/14 主分类号 C07D231/18
代理机构 代理人
主权项
地址