Interleukin-1beta converting enzyme inhibitors

摘要

The present invention relates to interleukin-1beta converting enzyme inhibitors having the formula: R is a carbocyclic or heterocyclic ring; R¹ is a cysteine trap; R^2a, R^2a', R^2b, and R^2b' are each independently hydrogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, and mixtures thereof; or R^2a' and R^2b' can taken together to form a double bond; L and L¹ are linking groups having the formula: T is selected from the group consisting of: i) -NR⁶-; ii) -O-; iii) -NR⁶S(O)₂-; iv) -S(O)₂NR⁶-; and v) mixtures thereof; R⁶ is hydrogen, substituted or unsubstituted C₁-C₂₀ linear, branched, or cyclic alkyl, C₆-C₂₀ aryl, C₇-C₂₀ alkylenearyl, and mixtures thereof; the indices w, w¹, and w² are each independently 0 or 1; i) hydrogen; ii) C₁-C₄ linear, branched, and cyclic alkyl; iii) R^3a and R^3b or R^4a, and R^4b can be taken together to form a carbonyl unit; iv) two R^3a or two R^3b units from adjacent carbon atoms or two R^4a or two R^4b units from adjacent carbon atoms can be taken together to form a double bond; and v) mixtures thereof; the index m is from 0 to 5; the index n is from 0 to 5.