<p>A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.</p>
申请公布号
CA2585836(A1)
申请公布日期
2006.05.04
申请号
CA20052585836
申请日期
2005.10.12
申请人
WARNER LAMBERT COMPANY LLC
发明人
SHALAEV, EVGENYI YUR'EVICH;QUALLICH, GEORGE JOSEPH;ZIEGLER, CARL BERNARD;ROSE, PETER ROBERT;DEBETTENCOURT, ANTONE JOHN, III