摘要 |
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes - and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others. |
申请人 |
BIOARRAY SOLUTIONS LTD.;REID, MARION, E.;SEUL, MICHAEL;HASHMI, GHAZALA;PIERCE, MICHAEL |
发明人 |
REID, MARION, E.;SEUL, MICHAEL;HASHMI, GHAZALA;PIERCE, MICHAEL |