发明名称 |
BISPECIFIC ANTIBODIES FOR INDUCING APOPTOSIS OF TUMOR AND DISEASED CELLS |
摘要 |
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention. |
申请公布号 |
EP1651663(A2) |
申请公布日期 |
2006.05.03 |
申请号 |
EP20040780644 |
申请日期 |
2004.08.09 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
CHANG, CHIEN-HSING;GOLDENBERG, DAVID, M.;HANSEN, HANS, J.;HORAK, EVA;HORAK, IVAN |
分类号 |
C07K16/28;A61K39/395;C07K;C07K14/00;C07K16/00;C07K16/30;C07K16/44;C07K16/46;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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