| 摘要 |
The present invention provides compositions and methods for enhancing cognitive function and synaptic plasticity. According to the method, Ca<SUP>++</SUP> influx into excitatory neurons (nerve cells) is decreased by treatment with a number of different agents including divalent cations (e.g., Mg<SUP>++</SUP>), GABA<SUB>B </SUB>agonists, GABA<SUB>A </SUB>agonists, calcium channel blockers, and/or compounds that decrease action potential firing such as sodium channel blockers. Decreasing Ca<SUP>++</SUP> influx results in increased synaptic plasticity and enhanced cognitive function. In particular, decreasing Ca<SUP>++</SUP> influx associated with uncorrelated neural activity results in long-lasting increases in synaptic plasticity and cognitive function. This is achieved by administration of agents that cause a voltage-dependent block of NMDA receptors (e.g., divalent cations such as Mg<SUP>++</SUP>) or by administration of GABA<SUB>B </SUB>agonists such as baclofen. The invention further provides screening methods useful in identifying compounds that enhance synaptic plasticity and cognitive function.
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