发明名称 |
MILCHSÄUREPOLYMER UND VERFAHREN ZU DESSEN HERSTELLUNG |
摘要 |
A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physlologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time. |
申请公布号 |
AT322513(T) |
申请公布日期 |
2006.04.15 |
申请号 |
AT20010954447T |
申请日期 |
2001.08.06 |
申请人 |
WAKO PURE CHEMICAL INDUSTRIES, LTD.;TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
YAMAMOTO, KOHEI;OAZA MATOBA, KAWAGOE-SHI;TANI, TSUTOMU;MATOBA, KAWAGOE-SHI;AOKI, TAKASHI;MATOBA, KAWAGOE-SHI;HATA, YOSHIO |
分类号 |
A61K9/16;A61K9/50;A61K9/52;C08G63/08;C08G63/88;C08G63/91;(IPC1-7):C08G63/88;A61K47/34 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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