PERFUSION CIRCUIT AND USE THEREIN IN TARGETED DELIVERY OF MACROMOLECULES

摘要

A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit (50) through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.