STABLE TETRODOTOXIN FREEZE DRYING MEDICINAL PREPARATION

摘要

The present invention provides a freeze-dried pharmaceutical formulation comprising tetrodotoxin or an analog thereof in an amount of 0.5-60 µg per dose, which has good stability and is safe for use by injection in humans and can be stored at room temperature for a long time. Said formulation also contains compounds, such as compounds containing glucosidic bonds selected from any one of disaccharides, ficolls, the derivatives thereof or their mixtures capable of reducing C-4 hydroxyl activity of the tetrodotoxin molecule or the analogs thereof, and a co-solvent(s) which improves solubility of tetrodotoxin or the analogs thereof.