N-aryl (thio) anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors

摘要

Described are compunds of formula (I), wherein W is O or S; X is NR₈; Y is CR₉R₁₀-(CH₂)_n wherein R₉ and R₁₀ are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO₂; R₁ is aryl; R₂ is a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms with the exception that R₂ cannot represent 2-phthalimidyl, and in case of Y-SO₂ cannot represent 2,1,3-benzothiadiazol-4-yl; any of R₃, R₄, R₅ and R₆, independently of the other, is H or a substituent other than hydrogen; and R₇ and R₈, independently of each, other, are H or lower alkyl; or a N-oxide or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical product for the treatment of a neoplastic disease which responds to an inhibition of the VEGF receptor tyrosine kinase activity. The compounds of formula (I) can be used for the treatment e.g. of a neoplastic disease, such as a tumor disease, of retinopathy and age-related macular degeneration.