ANIMAL EXHIBITING SHORT OR LONG PERIOD CIRCADIAN RHYTHM

摘要

PROBLEM TO BE SOLVED: To provide a model animal exhibiting a short or long period circadian rhythm. SOLUTION: The invention provides a non-human transgenic animal having extraneous PER2 gene. The transgenic animal exhibits a short or long-period circadian rhythm. Especially, a transgenic animal having a PER2 gene deleted in a nuclear transport sequence exhibits a long-period circadian rhythm. The invention further provides a method for preparing the transgenic animal and a method for screening a compound exerting an influence on sleep disorder by using the transgenic animal of the invention. COPYRIGHT: (C)2006,JPO&NCIPI