发明名称 |
AAV MEDIATED GENE DELIVERY TO COCHLEAR CELLS |
摘要 |
<p>The present invention is directed to a method of transducing mammalian cochlear cells, more preferably, cochlear hair cells and support cells. The method involves the delivery of adeno-associated virus (AAV) to a target mammalian cochlear cell. The AAV comprises DNA which is exogenous to the AAV and a promoter operatively linked to the DNA. Preferably, the promoter is a cell specific promoter, e.g., hair cell or support cell specific promoter, and the AAV is serotype 1, 2, 6, or a mixture of two or more serotypes. The present invention also relates to compositions comprising modified AAV useful in transducing specific cochlear cells.</p> |
申请公布号 |
WO2006033689(A2) |
申请公布日期 |
2006.03.30 |
申请号 |
WO2005US21486 |
申请日期 |
2005.06.17 |
申请人 |
THE UNIVERSITY OF MONTANA;POULSEN, DAVID;VONDOERSTEN, PETER;LURIE, DIANA;STONE, IDA |
发明人 |
POULSEN, DAVID;VONDOERSTEN, PETER;LURIE, DIANA;STONE, IDA |
分类号 |
A61K48/00;C12N15/861;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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